The changes caused by microcascular changes, such as vascular cognitive impairment, are often concurrent with other conditions such as Alzheimer’s disease, reports the Alzheimer’s Association. Glycolipid storage is variously and inconsistently reported in the cerebellar. Microinfarcts are frequently seen in gray and white matter, and the brain shows neuronal ischemia and fibrillary gliosis. Other causes of the disease include hypertension, diabetes, smoking, high cholesterol and a sedentary lifestyle, according to NetWellness. Neuropathological studies of Fabry's disease have demonstrated thickening of the meninges, macroscopic cortical infarcts, and cortical atrophy. MRI scan studies have revealed that increased levels of uric acid in the blood is one of the causes of cerebral microvascular disease, according to NIH. The small vessel diseases that result in microbleeds also cause larger brain bleeds. The disease has been linked to broader vascular conditions such as vascular dementia, a condition caused by the loss of blood supply to parts of the brain, according to the Alzheimer’s Association. Conceptually, brain microbleeds can be thought as very tiny amounts of blood (less than a drop) getting out of brain small vessels. The effects of diseased brain arterioles show up in imaging studies as subcortical lesions, as well as in strokes caused by the blockage of the small blood vessels that go deep into the brain, in microbleeds and in white matter lesions, according to NIH. Microvascular disease is caused by age-related changes in the brain and has also been linked to hypertension.
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